Drug intelligence / Profile preview

milrovekide

Development stage: Preclinical
Lead developer: Kalohexis
Modality: Peptides

Overview

Milrovekide (TCMC897) is a therapeutic peptide developed by Kalohexis that acts as a dual antagonist of the melanocortin 3 receptor (MC3R) and melanocortin 4 receptor (MC4R). It is specifically designed for the treatment of cancer cachexia in patients with advanced cancers. By antagonizing these central receptors, milrovekide aims to block the signaling pathways that drive appetite suppression and muscle wasting, thereby promoting weight maintenance or gain in cachectic patients. The drug is currently in the IND-enabling stage of development.

Targets

MC3R (Melanocortin Receptor Type 3)MC4R (Melanocortin 4 receptor)

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