miR-101a mimics

miR-101a mimics are synthetic double-stranded RNA molecules designed to mimic the function of endogenous microRNA-101a (miR-101a). They are widely used as research reagents in preclinical studies to investigate the therapeutic potential of miR-101a upregulation in various disease models, including osteoarthritis, cardiac fibrosis, spinal cord injury, and Parkinson's disease. miR-101a mimics function by binding to the 3'-untranslated region (3'-UTR) of target mRNAs, leading to translational repression or mRNA degradation. Key validated targets of miR-101a include cyclooxygenase-2 (COX-2), enhancer of zeste homolog 2 (EZH2), MYCN, and Rho-associated protein kinase 2 (ROCK2). In preclinical models of osteoarthritis, intra-articular injection of miR-101a mimics has been shown to attenuate chondrocyte hypertrophic differentiation and cartilage damage by directly targeting COX-2.

Other names

microRNA-101a mimicmicroRNA101a mimicmicroRNA 101a mimicmicroRNA-101a mimicsmicroRNA101a mimicsmicroRNA 101a mimicsmiR-101a mimicmiR101a mimicmiR 101a mimicmiR-101a-3p mimicmiR101a-3p mimicmiR 101a-3p mimicmiR-101a-3p mimicsmiR101a-3p mimicsmiR 101a-3p mimicsmmu-miR-101a-5p agomirsmmu-miR101a-5p agomirsmmu-miR 101a-5p agomirs