miR-125b

miR-125b is a highly conserved microRNA that serves as a critical post-transcriptional regulator of gene expression across various physiological and pathological states. It functions by binding to the 3' untranslated regions (UTRs) of target mRNAs, leading to their degradation or translational repression. miR-125b is implicated in a wide array of conditions; it acts as a tumor suppressor in breast and cervical cancers by targeting genes like TNFAIP3, but can also function as an oncomiR in hepatocellular carcinoma and myeloid leukemia. In inflammatory and fibrotic diseases, such as COPD and cardiac fibrosis, miR-125b modulates macrophage polarization and fibroblast activation, respectively, often through the p53 and TGF-β1/MAPK signaling pathways. Additionally, miR-125b is a significant biomarker and potential therapeutic target in neurodegenerative disorders like Alzheimer's disease, where its dysregulation is linked to tau hyperphosphorylation. Therapeutic strategies involving miR-125b include the use of miRNA mimics to restore its activity or antagomiRs to inhibit it, frequently utilizing exosomal or nanoparticle delivery systems.

Other names

microRNA-125bmicroRNA125bmicroRNA 125b