miR-125b lentivirus

miR-125b lentivirus is an experimental gene therapy construct consisting of a lentiviral vector designed to deliver and enforce the expression of microRNA-125b (miR-125b). miR-125b is a small non-coding RNA that functions as a key regulator of hematopoietic stem cell (HSC) and leukemia stem cell (LSC) maintenance by modulating the translation and stability of various target mRNAs. In preclinical studies of acute myeloid leukemia (AML), the use of this lentiviral vector to over-express miR-125b has been shown to promote the expansion of LSCs and multi-lymphoid progenitors (MLP), suggesting its role as an oncomiR that enhances self-renewal. This tool is primarily used in research settings to investigate the molecular mechanisms of leukemogenesis and stem cell biology.

Other names

miR-125b-expressing lentivirusmiR125b-expressing lentivirusmiR 125b-expressing lentiviruslentiviral miR-125b