miR-126

miR-126 is a microRNA (miRNA) that is highly expressed in endothelial cells and plays a pivotal role in maintaining vascular homeostasis, angiogenesis, and wound healing. In the context of oncology, miR-126 frequently functions as a tumor suppressor, and its expression is often significantly downregulated in various malignancies, including melanoma, breast cancer, and lung cancer. Research indicates that miR-126 modulates the tumor microenvironment by targeting the expression of proteins such as Vascular Cell Adhesion Molecule 1 (VCAM-1), thereby influencing tumor cell adhesion, migration, and invasiveness. Therapeutic strategies involving miR-126 typically focus on the use of miRNA mimics to restore its levels in cancer cells or the vasculature to inhibit tumor progression and improve clinical outcomes.

Other names

miR-126-3pmiR126-3pmiR 126-3pmiR-126-5pmiR126-5pmiR 126-5p