miR-126 mimic

miR-126 mimic is a synthetic double-stranded RNA oligonucleotide designed to mimic the endogenous microRNA miR-126 (typically the miR-126-3p strand), restoring or enhancing its function in target tissues. miR-126 is an endothelial-enriched microRNA that regulates angiogenesis, vascular integrity, and inflammatory signaling by post-transcriptional repression of targets in the VEGF/PI3K/Akt pathway, including phosphoinositide-3-kinase regulatory subunit 2 (PIK3R2/PI3KR2) and Sprouty-related protein SPRED1, and by modulating expression of vascular endothelial growth factor A (VEGF-A) and vascular cell adhesion molecule 1 (VCAM-1).[1][2][3][6][9][10][11] In preclinical studies, miR-126 mimics have been delivered to cells or ischemic tissues to normalize dysregulated VEGF-A signaling, reduce pathological angiogenesis (e.g., in diabetic retinopathy and hypoxia-induced retinal angiogenesis) or enhance reparative angiogenesis and perfusion in ischemic hind limb models, supporting their potential as an RNA-based therapeutic for vascular and ocular diseases.[1][2][4][9]

Other names

microRNA-126 mimicmicroRNA126 mimicmicroRNA 126 mimicmiR-126-3p mimicmiR126-3p mimicmiR 126-3p mimichsa-miR-126-3p mimichsa-miR126-3p mimichsa-miR 126-3p mimic