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miR-136

Development stage: Preclinical
Modality: RNA Therapeutics → Nucleic Acid Therapeutics
Administration: Intravenous, Intratumoral

Overview

miR-136 is a microRNA that acts as a tumor suppressor in various cancers, including glioblastoma. It functions by post-transcriptionally regulating gene expression, specifically targeting the 3'-untranslated region (UTR) of mRNAs such as CYR61 (Cysteine-rich angiogenic inducer 61). In glioblastoma models, miR-136 expression is up-regulated by the PPARα activator fenofibrate, leading to reduced cell proliferation. It has also been investigated for its role in other malignancies and biological processes like apoptosis and epithelial-mesenchymal transition (EMT).

Other names: hsa-miR-136hsa-miR136hsa-miR 136

Targets

Huntingtin messenger RNA CAG repeat tractBCL-2 (BCL-2 family)MMP9 (Matrix metalloproteinase-9)ROCK1 (Rho-associated coiled-coil containing protein kinase 1)MMP2 (Matrix metalloproteinase-2)CCN1 (Cellular communication network factor 5)

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