miR-137 mimic

miR-137 mimic is a synthetic double-stranded RNA molecule designed to restore the function of the endogenous tumor suppressor microRNA-137 (miR-137). In various cancers, particularly glioblastoma and colorectal cancer, miR-137 is frequently downregulated or silenced, often due to promoter hypermethylation. By mimicking the natural miRNA, this agent post-transcriptionally regulates gene expression by binding to the 3' untranslated regions (UTRs) of target mRNAs. This action leads to the inhibition of cell proliferation, induction of cell cycle arrest, and promotion of apoptosis. Preclinical studies in glioblastoma cell lines have demonstrated that miR-137 mimics can suppress the expression of key oncogenic and angiogenic factors, including EGFR, VEGF, and b-FGF, as well as invasive factors like MMP-2 and MMP-9. Furthermore, it inhibits survival signaling through the Akt and NF-κB pathways. Research indicates that miR-137 mimics may enhance the therapeutic efficacy of other agents, such as the flavonoid delphinidin and the DNA methylation inhibitor 5-aza-2′-deoxycytidine.

Other names

microRNA-137 mimicmicroRNA137 mimicmicroRNA 137 mimicprecursor miR-137 mimichsa-miR-137 mimichsa-miR137 mimichsa-miR 137 mimic