miR-145 lentiviral vector

A **miR-145 lentiviral vector** is a gene therapy research tool and experimental pharmaceutical based on a recombinant lentiviral vector engineered to express the microRNA miR-145. This construct is used to deliver and induce stable overexpression of miR-145 in target cells for preclinical or laboratory investigation. miR-145 functions as a tumor suppressor microRNA and its overexpression via lentiviral delivery has been shown to inhibit cancer cell proliferation, migration, invasion, EMT (epithelial-mesenchymal transition), stemness of cancer stem cells, and to induce apoptosis across various tumor models including liver cancer stem cells and esophageal carcinoma cells[1][2]. In metabolic disease models, lentiviral miR-145 reduces inflammatory pathways, macrophage infiltration, and improves glucose metabolism, partly by targeting OPG, KLF5, and downregulating NF-κB activation[3]. In liver cancer, it targets COL4A3 and modulates the Wnt/β-catenin and autophagy pathways[1]. The miR-145 lentiviral vector is most often used in research settings for both in vitro and in vivo studies and is not approved for clinical use.

Other names

miR-145 lentivirusmiR145 lentivirusmiR 145 lentiviruslv-miR-145lv-miR145lv-miR 145miR-145-5p lentiviral vectormiR145-5p lentiviral vectormiR 145-5p lentiviral vectormiR-145-5p-loaded lentivirusmiR145-5p-loaded lentivirusmiR 145-5p-loaded lentivirus