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miR-145-rich exosomes

Development stage: Preclinical
Modality: miRNA Mimics → MicroRNA (miRNA) → Small RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics, miRNA Inhibitors → MicroRNA (miRNA) → Small RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics, Lipid-based Nanoparticles → Nanoparticles → Drug Delivery Systems
Administration: Intravenous (tail-vein Injection In Mice)

Overview

miR-145-rich exosomes are mesenchymal stem cell-derived extracellular vesicles containing the microRNA miR-145. These exosomes are proposed to inhibit the migration of human umbilical vein endothelial cells (HUVECs) by targeting Junctional Adhesion Molecule A (JAM-A), which plays a role in the development of atherosclerosis. The exosomal miR-145 is associated with reducing atherosclerotic plaque formation by downregulating JAM-A expression both in vitro and in vivo.

Other names: MSC-derived miR-145-rich exosomes

Targets

JAM-A (Junctional adhesion molecule A)

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