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miR-146a-5p-loaded kidney-targeted exosomes
- Development stage
- Preclinical
- Lead developer
- Tongji Hospital
- Modality
- RNA Therapeutics → Nucleic Acid Therapeutics, Lipid-based Nanoparticles → Nanoparticles → Drug Delivery Systems
- Administration
- Intravenous
01
Overview
miR-146a-5p-loaded kidney-targeted exosomes is a preclinical exosome-based therapeutic candidate developed by Tongji Hospital of Tongji Medical College of Huazhong University of Science and Technology [P259]. It consists of exosomes modified with a peptide targeting intercellular adhesion molecule 1 (ICAM-1), which is highly expressed in the kidney tissues of patients and mice with calcium oxalate (CaOx) stones [P259]. The exosomes are loaded with miR-146a-5p mimics via electroporation [P259]. This drug delivery system is designed to target the kidneys and deliver miR-146a-5p, which inhibits M1 macrophage polarization through the IRAK1/TRAF6/IKK/NF-kappa B pathway, thereby reducing the formation of calcium oxalate stones and mitigating CaOx crystal-induced kidney injury [P259].
- Other names
- miR-146a-5p-loaded ICAM-1-targeted exosomesmiR146a-5p-loaded ICAM-1-targeted exosomesmiR 146a-5p-loaded ICAM-1-targeted exosomespeptide-modified exosomes targeting ICAM-1 loaded with miR-146a-5p
02
Targets
ICAM1 (Intercellular Adhesion Molecule 1)IRAK1 (Interleukin-1 receptor-associated kinase 1)TRAF6
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