miR-146a mimic

miR-146a mimics are synthetic double-stranded RNA oligonucleotides designed to replicate the biological activity of the endogenous microRNA miR-146a. As a microRNA replacement therapy, these mimics function by binding to the 3' untranslated regions (UTRs) of specific target mRNAs, leading to translational repression or mRNA degradation. Key validated targets include **TRAF6**, **IRAK1**, **SMAD4**, and **STAT1**. The therapeutic application of miR-146a mimics is context-dependent: in ophthalmology, they are investigated as anti-fibrotic agents to reduce subconjunctival fibrosis following glaucoma filtering surgery by inhibiting the NF-κB-SMAD4 signaling pathway. In oncology research, particularly in hepatocellular carcinoma (HCC), miR-146a mimics are used to study the microRNA's role as an oncogenic mediator of STAT3-induced immune suppression, where it promotes an immunosuppressive cytokine profile (e.g., increased TGF-β and IL-17, decreased IFN-α) that impairs natural killer (NK) cell activity.

Other names

microRNA-146a mimicmicroRNA146a mimicmicroRNA 146a mimicmiR-146a-5p mimicmiR146a-5p mimicmiR 146a-5p mimicmiR-146a mimicsmiR146a mimicsmiR 146a mimics