Clinical trials
Full profile accessFollow clinical development from study design and recruitment through results.
- Trial phase
- Status
- Readouts
Drug intelligence / Profile preview
miR-181d
- Development stage
- Preclinical
- Lead developer
- University of Minnesota
- Modality
- RNA Therapeutics → Nucleic Acid Therapeutics
- Administration
- Intratumoral
01
Overview
miR-181d is a microRNA being investigated as a therapeutic strategy for glioblastoma. It acts as a master regulator that simultaneously inhibits homologous recombination (HR) and base excision repair (BER) pathways by targeting RAD51 and O-6-methylguanine-DNA methyltransferase (MGMT). In glioblastoma, miR-181d levels are often decreased following temozolomide treatment, leading to the derepression of MGMT and RAD51, which confers resistance to chemotherapy and cross-resistance to ionizing radiation. Exogenous administration of miR-181d has been shown in preclinical models to sensitize glioblastoma cells to DNA-damaging agents by suppressing these repair mechanisms.
- Other names
- microRNA-181dmicroRNA181dmicroRNA 181dhsa-miR-181dhsa-miR181dhsa-miR 181d
02
Targets
RAD51 (RAD51 Recombinase)O-6-methylguanine-DNA methyltransferase mRNA (MGMT mRNA)
Beyond the preview
Go deeper on miR-181d.
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Indications & development
Full profile accessExplore development by indication, patient population, and geography.
- Indications
- Development status
- Countries
Licensing & deals
Full profile accessTrace asset ownership, licensing agreements, and commercial partnerships.
- Partners
- Deal terms
- Milestones
Patents & exclusivity
Full profile accessExplore the patent landscape and regulatory exclusivity around an asset.
- Patents
- Expiration dates
- Exclusivity
Competitive landscape
Full profile accessCompare development programs by target, modality, and indication.
- Competing assets
- Targets
- Development stage
Research & analysis
Full profile accessConnect source evidence and development news to your research questions.
- Publications
- News
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on miR-181d.