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miR-183-5p mimic
- Development stage
- Unknown
- Modality
- MicroRNA (miRNA) → Small RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics, Antisense Oligonucleotides (ASOs) → Long RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics, Antisense DNA → DNA Therapeutics → Nucleic Acid Therapeutics, Small Interfering RNA (siRNA) → Small RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics
- Administration
- Intrathecal
01
Overview
miR-183-5p mimic is a chemically synthesized, double-stranded RNA oligonucleotide designed to mimic the activity of endogenous microRNA-183-5p (miR-183-5p). It is primarily utilized as a research-use-only (RUO) tool to investigate the functional roles of miR-183-5p in various cellular processes, including tumor progression, metastasis, inflammation, and neuroprotection. By binding to the 3'-untranslated regions (3'-UTRs) of specific target mRNAs, such as PDCD4, TET1, and HMOX1, the mimic mediates translational repression or mRNA degradation of these target genes. In preclinical research, miR-183-5p mimics have been studied in models of breast cancer, prostate cancer, colorectal cancer, and intracerebral hemorrhage.
- Other names
- hsa-miR-183-5p mimichsa-miR183-5p mimichsa-miR 183-5p mimicmiR-183-5p mimicmiR183-5p mimicmiR 183-5p mimicmicroRNA-183-5p mimicmicroRNA183-5p mimicmicroRNA 183-5p mimic
02
Targets
HMOX1 (Heme oxygenase 1)
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