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miR-187-3p mimic
- Development stage
- Preclinical
- Lead developer
- RiboBio
- Modality
- Small Interfering RNA (siRNA) → Small RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics, MicroRNA (miRNA) → Small RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics, Antisense Oligonucleotides (ASOs) → Long RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics, Antisense DNA → DNA Therapeutics → Nucleic Acid Therapeutics
01
Overview
miR-187-3p mimic is a chemically synthesized, double-stranded RNA molecule designed to mimic the biological function of the endogenous microRNA miR-187-3p. As a microRNA agonist, it functions by binding to the 3' untranslated regions (UTRs) of specific messenger RNAs (mRNAs), leading to their degradation or the inhibition of their translation. In preclinical research, this mimic has been utilized to study its tumor-suppressive or protective effects in various conditions, including prostate cancer, clear cell renal cell carcinoma, colorectal cancer, and ischemia-reperfusion injury. It targets several genes depending on the disease context, such as FGFRL1, P2X7R, LRFN1, SPRY1, Seipin, and NIPBL. Currently, miR-187-3p mimic is used exclusively as a laboratory research tool and is not an approved therapeutic agent or a candidate in clinical trials.
- Other names
- microRNA-187-3p mimicmicroRNA187-3p mimicmicroRNA 187-3p mimichsa-miR-187-3p mimichsa-miR187-3p mimichsa-miR 187-3p mimic
02
Targets
BCL6 (B cell lymphoma 6 protein)Berardinelli-Seip congenital lipodystrophy 2 mRNA 3' untranslated region (BSCL2 mRNA 3'UTR)Cannabinoid receptor 2 mRNA 3' untranslated regionFibroblast growth factor receptor-like 1 mRNA 3' untranslated regionLeucine-rich repeat and fibronectin type III domain-containing protein 1 mRNA 3' untranslated regionP2X purinoceptor 7 mRNA 3' untranslated regionFGFR (FGFR family)NIPBL (NIPBL / Cornelia de Lange protein)P2RX7 (P2X purinoceptor 7)SPRY1 (Sprouty homolog 1)
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