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miR-199a-5p mimic
- Development stage
- Preclinical
- Modality
- MicroRNA (miRNA) → Small RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics, Antisense Oligonucleotides (ASOs) → Long RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics, Antisense DNA → DNA Therapeutics → Nucleic Acid Therapeutics, Small Interfering RNA (siRNA) → Small RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics
- Administration
- Intravenous
01
Overview
miR-199a-5p mimic is a chemically synthesized, double-stranded RNA molecule designed to simulate the activity of the endogenous microRNA miR-199a-5p. By increasing the intracellular levels of this miRNA, the mimic facilitates the down-regulation of specific target mRNAs through the RNA-induced silencing complex (RISC). In preclinical research, miR-199a-5p has been identified as a tumor suppressor in various cancers, including esophageal cancer and multiple myeloma, where it targets JUN-B and HIF-1α, respectively. It has also been investigated for its neuroprotective effects in ischemic stroke models by targeting Caveolin-1 and PIK3R2. Currently, it is primarily utilized as a research reagent and is not an approved therapeutic or in formal clinical development.
- Other names
- microRNA-199a-5p mimicmicroRNA199a-5p mimicmicroRNA 199a-5p mimichsa-miR-199a-5p mimichsa-miR199a-5p mimichsa-miR 199a-5p mimic
02
Targets
PIK3R2 (PI3K regulatory subunit beta)CAV1 (Caveolin-1)DRAM1 (DNA damage regulated autophagy modulator 1)JUNB (Transcription factor JunB mRNA)
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