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miR-1Zip
- Development stage
- Preclinical
- Lead developer
- System Biosciences
- Modality
- Lentiviral Vectors → Retroviral Vectors → Viral Vectors → Gene Addition/Replacement → Gene Therapies, RNA Therapeutics → Nucleic Acid Therapeutics
- Administration
- Intratumoral, Intravenous
01
Overview
miR-1Zip is a microRNA knockdown tool, specifically a lentiviral-based "miRZip" construct designed to permanently inhibit microRNA-1 (miR-1) activity. It functions as a microRNA sponge or decoy, expressing a short hairpin RNA that is processed into a competitive inhibitor which binds and sequesters mature miR-1. In oncological research, particularly in small cell lung cancer (SCLC), miR-1Zip is used to study the effects of miR-1 loss-of-function. Research indicates that inhibiting miR-1 with miR-1Zip leads to increased tumorigenesis and metastasis by derepressing the CXCR4/FOXM1/RRM2 signaling axis, confirming miR-1's role as a tumor suppressor.
- Other names
- miR-1 spongemiR1 spongemiR 1 spongemicroRNA-1 inhibitormicroRNA1 inhibitormicroRNA 1 inhibitor
02
Targets
miR-1 (MicroRNA-1)
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