mir-200b-3p agomir

mir-200b-3p agomir is a **synthetic, chemically-modified double-stranded RNA molecule** designed to mimic the mature endogenous microRNA miR-200b-3p, thereby increasing its activity within cells[3][9]. miR-200b-3p is a member of the miR-200 family of microRNAs, well known for regulating epithelial-mesenchymal transition (EMT), inhibiting tumor metastasis via direct inhibition of the ZEB1/2 transcription factors, and targeting other genes such as HMGB3, SMAD2, MAGP2, and TUBB3, among others[4][2]. As an agomir, this molecule is used to upregulate the effects of miR-200b-3p, which include **inhibiting EMT, suppressing tumor cell proliferation, invasion, and migration**, and improving **chemosensitivity (e.g., to 5-fluorouracil in colorectal cancer cells)** by downregulating HMGB3/\u03b2-catenin/c-Myc signaling[2][4]. miR-200b-3p also regulates NF-\u03baB and IRF3-mediated interferon production by targeting TBK1, indicating a role in antiviral immunity, although the agomir itself is typically used in cancer research rather than antiviral therapy[1][8].

Other names

miR-200b-3p agomirmiR200b-3p agomirmiR 200b-3p agomirmiR-200b-3p mimicmiR200b-3p mimicmiR 200b-3p mimichsa-miR-200b-3p agomirhsa-miR200b-3p agomirhsa-miR 200b-3p agomirrno-miR-200b-3p agomirrno-miR200b-3p agomirrno-miR 200b-3p agomir