miR-208a-5p inhibitor

A **miR-208a-5p inhibitor** is a synthetic antisense oligonucleotide, typically modified with locked nucleic acid (LNA) technology, designed to bind and inhibit the activity of microRNA miR-208a-5p. miR-208a is a cardiac-specific microRNA involved in the regulation of gene expression associated with cardiac hypertrophy, fibrosis, and heart failure. Inhibition of miR-208a with LNA-antimiR oligonucleotides in animal models has been shown to reduce cardiac pathological remodeling, blunt functional deterioration, and improve survival during heart disease, with minimal observed adverse effects. The primary mechanism involves sequence-specific binding to miR-208a, thereby preventing its regulatory action on target transcripts such as Myh7 (encoding beta-myosin heavy chain). In experimental settings, miR-208a inhibitors are also used to investigate oncogenic roles of miR-208a in cancer, where inhibition can attenuate proliferation and invasion of non-small cell lung cancer (NSCLC) cells[1][2][3][4][6].

Other names

miR-208a inhibitormiR208a inhibitormiR 208a inhibitorantimiR-208aantimiR208aantimiR 208aanti-miR-208aanti-miR208aanti-miR 208amiR-208a antisense oligonucleotidemiR208a antisense oligonucleotidemiR 208a antisense oligonucleotide