miR-210 mimic

miR-210 mimic is a synthetic double-stranded microRNA designed to mimic the activity of endogenous mature miR-210, a master regulator of the cellular response to hypoxia. In preclinical research, miR-210 mimics are used to restore or overexpress miR-210 levels, which are often downregulated in metabolic and cardiovascular diseases such as metabolic dysfunction-associated steatotic liver disease (MASLD), type 2 diabetes, and peripheral artery disease. Mechanistically, miR-210 mimic acts by post-transcriptionally silencing target genes involved in lipid metabolism, oxidative stress, and cell survival, including cell death-inducing DFFA-like effector C (CIDEC), protein tyrosine phosphatase 1B (PTP1B), and adenomatous polyposis coli (APC). Overexpression of miR-210 via mimics has been shown to reduce hepatic lipid accumulation, improve endothelial function, and promote angiogenesis in various animal models.

Other names

microRNA-210 mimicmicroRNA210 mimicmicroRNA 210 mimicmiR-210-3p mimicmiR210-3p mimicmiR 210-3p mimicprecursor miR-210 mimic