miR-211

miR-211 is a microRNA that plays a complex and context-dependent role in melanoma, with evidence supporting both tumor-suppressive and oncogenic functions. In the context of BRAF-mutant melanoma, miR-211 has been shown to act as an oncogenic driver that promotes aggressive tumor growth, angiogenesis, and resistance to BRAF inhibitors (e.g., vemurafenib) and MEK inhibitors (e.g., cobimetinib). It exerts these effects by directly targeting and downregulating the expression of BIRC2 and DUSP6, which in turn leads to the activation of the ERK5 signaling pathway. Additionally, miR-211 influences the epigenetic landscape of melanoma cells through modifications such as H3K27me3 and H3K4me3. Research involving Regulus Therapeutics and academic institutions suggests that targeting the miR-211-ERK5 axis may be a viable strategy for overcoming drug resistance and inhibiting melanoma progression.

Other names

microRNA-211microRNA211microRNA 211hsa-miR-211hsa-miR211hsa-miR 211MIR211MIR-211MIR 211