miR-22

miR-22 is an endogenous, evolutionarily conserved microRNA of approximately 22 nucleotides in length, involved in the post-transcriptional regulation of gene expression by binding to the 3' UTR of target mRNAs. It acts as both a tumor suppressor and, in some contexts, an oncogene depending on the specific cellular environment. miR-22 regulates cancer cell proliferation, senescence, migration, invasion, metastasis, apoptosis, and epithelial-mesenchymal transition by targeting several genes, notably including histone deacetylase 4 (HDAC4), Myc Binding Protein (MYCBP), metadherin (MTDH), matrix metalloproteinase 14 (MMP14), and Snail. Overexpression or modulation of miR-22 has shown potential in preclinical models to inhibit tumor growth and metastasis, highlighting it as a candidate RNA therapeutic and cancer biomarker. As of now, miR-22 is chiefly an experimental molecule, and not yet an approved drug therapy[1][2][3][4].

Other names

microRNA-22microRNA22microRNA 22hsa-miR-22hsa-miR22hsa-miR 22mir-22 microRNAmir22 microRNAmir 22 microRNA