miR-25 lentiviral vector

miR-25 lentiviral vector is a gene therapy tool designed to overexpress microRNA-25 (miR-25) within target cells. In research concerning Acute Myeloid Leukemia (AML), miR-25 has been identified as a component of the miR-106b-25 cluster that contributes to chemoresistance and the evasion of apoptosis. The vector functions by delivering the miR-25 sequence, which subsequently targets and downregulates the expression of pro-apoptotic factors, specifically BAK1 and Caspase-7. This tool is primarily utilized in preclinical studies to model the oncogenic effects of miR-25 and to evaluate its impact on drug sensitivity in leukemic cell lines and xenograft models.

Other names

lentiviral miR-25miR-25 overexpression vectormiR25 overexpression vectormiR 25 overexpression vectormiR-25 lentivirusmiR25 lentivirusmiR 25 lentivirus