miR-302a mimics

miR-302a mimics are synthetic double-stranded RNA oligonucleotides designed to mimic the activity of endogenous microRNA-302a (miR-302a). In preclinical research, these mimics are transfected into cells to study the post-transcriptional regulation of gene expression. miR-302a acts as a tumor suppressor in various cancers, including breast cancer, osteosarcoma, acute myeloid leukemia, and colorectal cancer, by directly targeting and downregulating genes involved in cell proliferation, survival, metastasis, and drug resistance. Key validated targets of miR-302a include AKT1, RAD52, IGF1R, NFIB, CD44, and IRF5. Overexpression of miR-302a via synthetic mimics has been shown to sensitize cancer cells to radiotherapy and chemotherapy, and to modulate inflammatory cytokine production during viral infections.

Other names

miR-302a mimicmiR302a mimicmiR 302a mimicmiR-302a-3p mimicmiR302a-3p mimicmiR 302a-3p mimicmiR-302a-5p mimicmiR302a-5p mimicmiR 302a-5p mimicmicroRNA-302a mimicmicroRNA302a mimicmicroRNA 302a mimicmicroRNA-302a mimicsmicroRNA302a mimicsmicroRNA 302a mimics