miR-3619-5p mimic

miR-3619-5p mimic is a synthetic double-stranded RNA molecule designed to mimic the endogenous tumor-suppressive microRNA miR-3619-5p. In esophageal squamous cell carcinoma (ESCC), miR-3619-5p levels are often depleted, leading to the overexpression of its target oncogene, PIM1 (proviral insertion site in Moloney murine leukemia virus 1). By restoring miR-3619-5p levels, the mimic directly binds to the 3' UTR of PIM1 mRNA, leading to its degradation or translational inhibition. This suppression results in reduced AKT phosphorylation, increased p21 expression, and subsequent inhibition of cell proliferation, migration, and invasion. Research conducted at the Kyoto Prefectural University of Medicine has demonstrated that systemic delivery of this mimic (e.g., via atelocollagen-complexed subcutaneous injection) can significantly inhibit tumor growth in xenograft models without significant systemic toxicity.

Other names

hsa-miR-3619-5p mimichsa-miR3619-5p mimichsa-miR 3619-5p mimicmicroRNA-3619-5p mimicmicroRNA3619-5p mimicmicroRNA 3619-5p mimic