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miR-369-5p lentiviral silencing
- Development stage
- Unknown
- Lead developer
- Baylor College of Medicine
- Modality
- Gene Therapies, RNA Therapeutics → Nucleic Acid Therapeutics
- Administration
- Intratumoral
01
Overview
miR-369-5p lentiviral silencing is an experimental gene therapy approach designed to inhibit the invasion of glioblastoma multiforme (GBM) cells. miR-369-5p was identified as a microRNA significantly upregulated in invasive GBM cells compared to the tumor core. By utilizing a lentiviral vector to deliver silencing machinery (such as shRNA) against miR-369-5p, researchers observed a suppression of GBM cell migration in vitro and a significant inhibition of invasive growth in vivo using patient-derived orthotopic xenograft (PDOX) models. The silencing of miR-369-5p appears to modulate the expression of target genes like RDX and MANEA, which are involved in tumor cell motility and invasion.
- Other names
- lentivirus-mediated silencing of miR-369-5p
02
Targets
miR-369-5p (MicroRNA 369-5p)
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