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miR-4262 mimics
- Development stage
- Unknown
- Modality
- MicroRNA (miRNA) → Small RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics, Antisense Oligonucleotides (ASOs) → Long RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics, Antisense DNA → DNA Therapeutics → Nucleic Acid Therapeutics, Small Interfering RNA (siRNA) → Small RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics
- Administration
- Intravenous
01
Overview
miR-4262 mimics are chemically synthesized double-stranded RNA molecules designed to emulate the function of the endogenous microRNA miR-4262. These mimics are used to upregulate miR-4262 activity for functional analysis in various disease models. In preclinical research for gastric cancer, miR-4262 mimics have been shown to suppress cell proliferation and invasion and promote apoptosis by targeting the CD163 gene. Conversely, in non-small cell lung cancer (NSCLC), miR-4262 has been identified as a factor that enhances paclitaxel resistance by targeting PTEN and activating the PI3K/Akt signaling pathway. Currently, miR-4262 mimics are primarily utilized as research-grade reagents and are not known to be in active clinical development as therapeutic assets by a specific pharmaceutical sponsor.
- Other names
- microRNA-4262 mimicsmicroRNA4262 mimicsmicroRNA 4262 mimicshsa-miR-4262 mimicshsa-miR4262 mimicshsa-miR 4262 mimics
02
Targets
PTEN (Phosphatase and tensin homolog deleted on chromosome ten)
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