miR-4284 inhibitor

miR-4284 inhibitor is a synthetic oligonucleotide-based research reagent designed to silence microRNA-4284 (miR-4284). As an antagomir or anti-miR, it hybridizes with mature miR-4284 to prevent its interaction with target genes. In preclinical models, miR-4284 inhibition has demonstrated therapeutic potential across several diseases. In Alzheimer's disease models, it reduces amyloid-beta accumulation, apoptosis, and neuroinflammation by de-repressing amyloid beta precursor protein binding protein family A member 1 (APBA1) and modulating JAK/STAT3 signaling. In non-small cell lung cancer (NSCLC) cells, it suppresses tumor cell proliferation, migration, and invasion, an effect that can be enhanced by ultrasound-targeted microbubble destruction (UTMD). Additionally, in paclitaxel-resistant ovarian carcinoma cells, miR-4284 depletion de-represses DNA meiotic recombinase 1 (DMC1) to suppress cell proliferation and cell cycle progression. It is currently utilized strictly as a research tool with no active clinical development.

Other names

hsa-miR-4284 antagomirhsa-miR4284 antagomirhsa-miR 4284 antagomirhsa-miR-4284 inhibitorhsa-miR4284 inhibitorhsa-miR 4284 inhibitorhsa-miR-4284 miRNA Inhibitorhsa-miR4284 miRNA Inhibitorhsa-miR 4284 miRNA InhibitormiR-4284-ImiR4284-ImiR 4284-I