Drug intelligence / Profile preview

miR-483-3p inhibitor

Development stage
Preclinical
Modality
MicroRNA (miRNA) → Small RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics, Antisense Oligonucleotides (ASOs) → Long RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics, Antisense DNA → DNA Therapeutics → Nucleic Acid Therapeutics, Small Interfering RNA (siRNA) → Small RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics
Administration
Intraperitoneal, Subcutaneous, Intravenous, In Vitro Transfection
01

Overview

miR-483-3p inhibitor is a **sequence-specific oligonucleotide RNA therapy** intended to suppress the activity of microRNA-483-3p. In the provided publication context, it was used experimentally in an in vitro lipopolysaccharide-induced sepsis intestinal injury model, where inhibition of miR-483-3p reduced epithelial cell apoptosis and cytotoxicity, with the reported effect mediated through derepression of **homeodomain interacting protein kinase 2**. The term does not identify a single named clinical candidate, company-sponsored asset, or standardized commercial product; rather, it refers generically to an anti-miR research reagent or therapeutic concept directed against miR-483-3p.

Other names
miR-483-3p inhibitormiR483-3p inhibitormiR 483-3p inhibitormicroRNA-483-3p inhibitormicroRNA483-3p inhibitormicroRNA 483-3p inhibitormiRNA-483-3p inhibitormiRNA483-3p inhibitormiRNA 483-3p inhibitor
02

Targets

BIRC5 (Survivin)Renin-angiotensin system component messenger RNA 3'-untranslated regions

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