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miR-493
- Development stage
- Preclinical
- Lead developer
- University of California, San Francisco
- Modality
- RNA Therapeutics → Nucleic Acid Therapeutics
01
Overview
miR-493 is a tumor-suppressive microRNA that plays a significant role in regulating cancer cell proliferation, migration, and invasion. It is frequently down-regulated in various malignancies, including bladder cancer, liver cancer, and lung cancer. As a therapeutic approach, miR-493 mimics are investigated to restore its expression and inhibit oncogenic pathways. Its mechanism involves the direct targeting and down-regulation of several oncogenes, most notably RhoC (Ras homolog gene family, member C) and FZD4 (Frizzled-4), which are involved in the Wnt signaling pathway and cytoskeletal remodeling. By suppressing these targets, miR-493 inhibits the RhoC/ROCK1 signaling axis, thereby reducing cell motility and metastatic potential.
- Other names
- microRNA-493microRNA493microRNA 493hsa-miR-493hsa-miR493hsa-miR 493MIR493MIR-493MIR 493
02
Targets
FZD4 (Frizzled class receptor 4)RHOC (Ras homolog family member C)
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