Drug intelligence / Profile preview

miR-496 mimic

Development stage
Unknown
Modality
MicroRNA (miRNA) → Small RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics, Antisense Oligonucleotides (ASOs) → Long RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics, Antisense DNA → DNA Therapeutics → Nucleic Acid Therapeutics, Small Interfering RNA (siRNA) → Small RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics
Administration
Intravenous, Subcutaneous, Intratumoral, Inhalation, Intranasal
01

Overview

miR-496 mimic is a research-stage synthetic double-stranded RNA molecule designed to mimic the endogenous microRNA miR-496. In preclinical studies, particularly in gastric cancer and triple-negative breast cancer, miR-496 mimic has been shown to inhibit cell proliferation, migration, and invasion, and to induce apoptosis. It exerts its effects primarily by targeting LYN kinase (LYN) and suppressing the downstream AKT/mTOR signaling pathway, as well as targeting developmentally regulated endothelial cell locus 1 (Del-1/EDIL3). The compound is primarily sourced from reagent suppliers such as GenePharma and MedChemExpress for laboratory research, and there is no formal clinical development program or approved therapeutic indication associated with it.

Other names
hsa-miR-496 agomirhsa-miR496 agomirhsa-miR 496 agomirhsa-miR-496 mimichsa-miR496 mimichsa-miR 496 mimicmicroRNA-496 mimicmicroRNA496 mimicmicroRNA 496 mimicmiR-496 agomirmiR496 agomirmiR 496 agomir
02

Targets

DEL-1 (EGF-like repeat and discoidin I-like domain-containing protein 3 (EDIL3))LYN (LYN proto-oncogene, Src family tyrosine kinase)mTOR (Mammalian target of rapamycin kinase)CTNNB1 (Beta-catenin)

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