miR-506-3p mimic

miR-506-3p mimic is a synthetic, double-stranded RNA oligonucleotide designed to mimic the function of the endogenous human microRNA hsa-miR-506-3p. As a microRNA therapeutic, it functions by binding to the 3' untranslated regions (UTRs) of multiple target mRNAs, leading to translational inhibition or mRNA degradation. Key targets identified in preclinical studies include S6K1, EZH2, KLF4, and FOXP1. In oncology, miR-506-3p acts as a tumor suppressor; its mimic has been shown to induce cell differentiation in neuroblastoma, promote apoptosis and senescence in pancreatic carcinoma, and sensitize ovarian cancer cells to chemotherapy and PARP inhibitors. Additionally, it has been investigated for its role in metabolic disorders by modulating the PI3K/AKT signaling pathway. Currently, the compound is primarily used as a research tool in in vitro and in vivo models, with no specific clinical development program identified.

Other names

hsa-miR-506-3p mimichsa-miR506-3p mimichsa-miR 506-3p mimicmicroRNA-506-3p mimicmicroRNA506-3p mimicmicroRNA 506-3p mimic