miR-520b mimics

**miR-520b mimics** are synthetic RNA oligonucleotides designed to replicate the function of the endogenous human microRNA miR-520b. These mimics are used experimentally to increase cellular miR-520b activity, enabling the study or modulation of miR-520b-regulated cellular pathways. Mechanistically, miR-520b targets multiple mRNAs associated with cancer progression, stemness, epithelial-mesenchymal transition (EMT), and drug resistance, functioning primarily as a tumor suppressor. Direct targets include CD44[1], MEKK2 and cyclin D1[2], Rab22A[3][6], PTEN[4], and IGF1R[10], among others. Preclinical studies have shown that treatment with miR-520b mimics inhibits cell proliferation, migration, invasion, and EMT, and increases chemosensitivity and apoptosis in cancer cell lines, as well as suppresses tumor growth in xenograft models[1][2][3][5][6][10]. Due to their mechanism as non-coding RNA-based gene regulators, they are considered investigational RNA therapies, predominantly developed and utilized in research settings for cancers such as hepatocellular carcinoma, non-small cell lung cancer, breast cancer, gallbladder carcinoma, and head and neck cancer.

Other names

miR-520b mimicmiR520b mimicmiR 520b mimicmicroRNA-520b mimicmicroRNA520b mimicmicroRNA 520b mimichsa-miR-520b mimichsa-miR520b mimichsa-miR 520b mimic