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miR-603 + PEI liposome + PR_b-targeted
- Development stage
- Preclinical
- Lead developer
- Johns Hopkins University
- Modality
- RNA Therapeutics → Nucleic Acid Therapeutics, Lipid-based Nanoparticles → Nanoparticles → Drug Delivery Systems
- Administration
- Intratumoral
01
Overview
**miR-603 + PEI liposome + PR_b-targeted** is an academic, preclinical targeted microRNA nanomedicine for glioblastoma. The formulation complexes miR-603 with polyethylenimine and encapsulates the complex in PEGylated liposomes functionalized with the fibronectin-mimetic peptide PR_b, which targets integrin alpha-5/beta-1 on glioblastoma cells. Delivered miR-603 reduces insulin-like growth factor 1 and insulin-like growth factor 1 receptor expression, suppressing glioblastoma stem-like cell-state and radiation resistance and sensitizing patient-derived glioblastoma cells to ionizing radiation. ([mdpi.com](https://www.mdpi.com/1999-4923/13/8/1115))
- Other names
- PR_b-functionalized PEGylated liposomes encapsulating miR-603/PEI complexesPR_b liposomes encapsulating miR-603/PEI
02
Targets
IGF-1R (Insulin-like growth factor 1 receptor)IGF-1 (Insulin-like growth factor 1)ITGA5:ITGB1 (Integrin α5β1)
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