miR-7 loaded exosomes

miR-7 loaded exosomes are an experimental therapeutic modality utilizing extracellular vesicles (exosomes) to deliver microRNA-7 (miR-7) to target cells, primarily for the treatment of various cancers such as glioblastoma and pancreatic adenocarcinoma. miR-7 is a potent tumor suppressor that downregulates multiple oncogenic signaling pathways by binding to the 3' untranslated regions (UTRs) of target mRNAs, including EGFR, IGF-1R, and members of the PI3K/Akt pathway. By encapsulating miR-7 within exosomes—often derived from mesenchymal stem cells (MSCs) or engineered donor cells—the microRNA is protected from degradation in the systemic circulation and can be delivered with enhanced bioavailability and potentially reduced immunogenicity compared to synthetic nanoparticles. This approach aims to restore miR-7 levels in tumors where it is frequently downregulated, thereby inhibiting cell proliferation, migration, and angiogenesis.

Other names

miR-7-loaded exosomesmiR7-loaded exosomesmiR 7-loaded exosomesexosomal miR-7MSC-derived miR-7 exosomes