miR-708

miR-708 is a tumor-suppressive microRNA that regulates gene expression post-transcriptionally by binding to the 3'-untranslated regions (3'-UTR) of target mRNAs. In renal cell carcinoma (RCC), miR-708 expression is frequently downregulated, often due to epigenetic silencing via histone deacetylation. Restoration of miR-708 levels, either through pharmacological induction or exogenous delivery of miR-708 mimics, has been shown to inhibit tumor cell growth, clonability, invasiveness, and migration. Its primary mechanism of action involves the direct targeting and downregulation of survivin (BIRC5), a member of the inhibitor of apoptosis (IAP) protein family that is critical for cancer cell survival and progression. Preclinical evidence, including intratumoral delivery in xenograft models, supports the potential of miR-708 as a therapeutic strategy for suppressing tumorigenicity in RCC.

Other names

microRNA-708microRNA708microRNA 708