miR-93 lentiviral vector

miR-93 lentiviral vector is an experimental gene therapy construct designed to overexpress microRNA-93 (miR-93). In the context of hematological malignancies such as Acute Myeloid Leukemia (AML), miR-93 is recognized as a member of the miR-106b-25 cluster that contributes to chemoresistance and accelerated cell growth. The vector functions by delivering the miR-93 sequence into target cells, where the resulting miRNA overexpression leads to the downregulation of pro-apoptotic targets, specifically Tumor protein p73 (TP73) and Caspase-7. This suppression of apoptotic pathways promotes leukemic cell survival and resistance to treatments such as doxorubicin and BCL-2 inhibitors. It is primarily utilized as a research tool in preclinical models to elucidate the mechanisms of drug resistance and oncogenesis.

Other names

lentiviral miR-93miR-93-expressing lentiviral vectormiR93-expressing lentiviral vectormiR 93-expressing lentiviral vector