miR-9985-loaded extracellular vesicles

miR-9985-loaded extracellular vesicles is an engineered exosome-based therapy under preclinical development for the treatment of lung adenocarcinoma. Developed by researchers at Korea University, the therapy consists of mesenchymal stem cell (MSC)-derived extracellular vesicles (EVs) engineered to carry miR-9985, a microRNA that targets GRIP and coiled-coil domain-containing 2 (GCC2). GCC2 is a trans-Golgi network protein that acts as a key regulator of EV secretion and tumor cell survival in lung adenocarcinoma. By delivering miR-9985, these engineered EVs reduce GCC2 expression, suppress EV secretion, and promote apoptosis in lung adenocarcinoma cells, demonstrating significant antitumor efficacy in preclinical in vitro and in vivo models.

Other names

mesenchymal stem cell-derived extracellular vesicles carrying miR-9985miR-9985-loaded EVsmiR9985-loaded EVsmiR 9985-loaded EVsMSC-derived EVs carrying miR-9985