miR506-3p

miR506-3p is a tumor-suppressive microRNA (the 3p arm of miR-506) that post-transcriptionally regulates multiple oncogenic pathways by binding complementary sites in target mRNA 3′UTRs and inducing mRNA degradation or translational repression. It is downregulated in several malignancies, including osteosarcoma, pancreatic ductal adenocarcinoma, ovarian cancer, liver cancer, lung cancer, and lung carcinoma, where its restoration via synthetic mimics or agomirs inhibits proliferation, invasion, metastasis, epithelial–mesenchymal transition, and promotes apoptosis, senescence, differentiation, and reactive oxygen species–mediated cell death.[1][3][4][5][6] Identified direct or functional targets include RAB3D and CDK4 in osteosarcoma, PIM-3 and multiple survival/autophagy regulators in pancreatic cancer, CDK4/6–FOXM1 and metastasis-related genes in ovarian cancer, MTMR6 and SIRT1 in liver or lung carcinoma, and a broader “targetome” of differentiation-modulating genes in neuroblastoma, making miR506-3p a candidate therapeutic agent for miRNA replacement or differentiation therapy using nanoparticle or agomir delivery systems.[1][3][4][5][6]

Other names

microRNA-506-3pmicroRNA506-3pmicroRNA 506-3pmiR-506-3pmiR506-3pmiR 506-3pmiRNA-506-3pmiRNA506-3pmiRNA 506-3pmiR506miR-506miR 506