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mirabegron + tolterodine
- Development stage
- Unknown
- Lead developer
- Astellas Pharma
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
**mirabegron + tolterodine** is a *combination drug* used to treat overactive bladder (OAB). **Mirabegron** is a β₃-adrenoceptor agonist, while **tolterodine** is a muscarinic receptor antagonist (antimuscarinic). Their combined use targets different pathways in bladder control: mirabegron relaxes the detrusor muscle by stimulating β₃-adrenoceptors, increasing bladder capacity, while tolterodine decreases involuntary bladder contractions by blocking muscarinic receptors. This combination is used for patients with OAB to reduce urinary frequency, urgency, and incontinence, particularly in cases resistant to monotherapy. Clinical and animal studies show the combination can normalize bladder parameters and improve outcomes, potentially with lower risk of anticholinergic side effects compared to higher-dose antimuscarinics alone[2][3].
- Other names
- mirabegron + tolterodine
02
Targets
CHRM2 (M2)CHRM3 (M3)ADRB3 (β3)
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