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miRacle

Development stage: Preclinical
Lead developer: SirtLab
Modality: Antisense Oligonucleotides (ASOs) → Long RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics, Modified DNA Oligonucleotides → Antisense DNA → DNA Therapeutics → Nucleic Acid Therapeutics, Single-strand DNA → Antisense DNA → DNA Therapeutics → Nucleic Acid Therapeutics
Administration: Oral

Overview

miRacle is a preclinical-stage therapeutic candidate developed by SirtLab. It utilizes a dual anti-miRNA oligonucleotide approach designed to inhibit specific microRNAs (miRNAs) that naturally suppress the expression of Sirtuin 6 (SIRT6). By blocking these inhibitory miRNAs, miRacle aims to increase the activity and expression levels of SIRT6, a protein known for its critical roles in DNA repair, metabolic regulation, and longevity. The drug is being investigated for a broad range of indications, including cancer, cardiovascular diseases, metabolic disorders, and neurodegenerative diseases.

Targets

SIRT6 (Sirtuin 6)SIRT6-miRNAs (MicroRNAs targeting Sirtuin 6 mRNA)SIRT6-AS1 (Sirtuin 6 natural antisense transcript)

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