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miricorilant

Development stage: Phase 2
Lead developer: Corcept Therapeutics
Modality: Allosteric Modulators → Classical Binding Small Molecules → Small Molecules, Orthosteric Ligands → Classical Binding Small Molecules → Small Molecules

Overview

Miricorilant is an investigational, oral, nonsteroidal small molecule that acts as a selective glucocorticoid receptor modulator (SGRM) and mineralocorticoid receptor antagonist. It is being developed primarily by Corcept Therapeutics for the treatment of metabolic diseases such as nonalcoholic steatohepatitis (NASH), metabolic dysfunction-associated steatohepatitis (MASH), weight gain associated with antipsychotic use in schizophrenia, and alcoholism. Miricorilant has demonstrated activity in reducing liver fat and improving hepatic, lipid, and glycemic markers in clinical studies. Its mechanism involves antagonism of both the glucocorticoid receptor and mineralocorticoid receptor pathways[3][9][4].

Other names: miricorilant [INN]miricorilant [USAN]

Targets

GR (Glucocorticoid receptor)MR (Mineralocorticoid receptor)

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