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Drug intelligence / Profile preview
miricorilant
- Development stage
- Phase 2
- Lead developer
- Corcept Therapeutics
- Modality
- Orthosteric Ligands → Classical Binding Small Molecules → Small Molecules, Allosteric Modulators → Classical Binding Small Molecules → Small Molecules
01
Overview
Miricorilant is an investigational, oral, nonsteroidal small molecule that acts as a selective glucocorticoid receptor modulator (SGRM) and mineralocorticoid receptor antagonist. It is being developed primarily by Corcept Therapeutics for the treatment of metabolic diseases such as nonalcoholic steatohepatitis (NASH), metabolic dysfunction-associated steatohepatitis (MASH), weight gain associated with antipsychotic use in schizophrenia, and alcoholism. Miricorilant has demonstrated activity in reducing liver fat and improving hepatic, lipid, and glycemic markers in clinical studies. Its mechanism involves antagonism of both the glucocorticoid receptor and mineralocorticoid receptor pathways[3][9][4].
- Other names
- miricorilant [INN]miricorilant [USAN]
02
Targets
GR (Glucocorticoid receptor)MR (Mineralocorticoid receptor)
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