mirimostim

Mirimostim is a recombinant form of **macrophage colony-stimulating factor** (M-CSF), also known as colony-stimulating factor 1 (CSF-1). It acts as an **immunomodulator**, primarily promoting the activation and proliferation of macrophages, which are crucial for hematopoiesis, immune responses, and tissue regeneration. Mirimostim has been used to facilitate **white blood cell production**, particularly after chemotherapy-induced neutropenia. Mechanistically, it targets the **colony-stimulating factor 1 receptor (CSF-1R)** to stimulate macrophage growth and function, enhance wound healing, and promote angiogenesis and tissue repair. Clinical use and studies have focused on mitigating immunological impairment following chemotherapy, by improving NK cell activity, Th1/Th2 balance, and granulocyte function[1][3][7][10].

Brand names

CostilateLeukoprol

Other names

mirimostim