miRNA-133a mimics

**miRNA-133a mimics** are synthetic double-stranded oligonucleotides designed to mimic the endogenous microRNA-133a, primarily to restore or enhance miR-133a activity in tissues where its expression is diminished, such as in cardiac muscle following myocardial infarction. These mimics act by binding to specific mRNA targets (such as Apaf-1 and DAPK2), leading to downregulation of pro-apoptotic genes and promotion of cell survival, decreased apoptosis, improved cell function, and reduced fibrosis[1][5][9]. Their therapeutic use is being explored in models of cardiovascular disease and tissue regeneration. The mechanism involves RNA-induced silencing complex (RISC)–mediated repression of target mRNA translation or stability[1][5]. miRNA therapeutics are under preclinical investigation for heart failure, ischemia-reperfusion injury, and other indications[4][8].

Other names

miR-133a mimicsmiR133a mimicsmiR 133a mimicsmiRNA-133a-3p mimicsmiRNA133a-3p mimicsmiRNA 133a-3p mimicshsa-miR-133a-3p mimichsa-miR133a-3p mimichsa-miR 133a-3p mimic