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miRNA-6883 lipid nanoparticles
- Development stage
- Preclinical
- Lead developer
- SMURF Therapeutics
- Modality
- RNA Therapeutics → Nucleic Acid Therapeutics, Lipid-based Nanoparticles → Nanoparticles → Drug Delivery Systems
- Administration
- Injection
01
Overview
miRNA-6883 lipid nanoparticles are an experimental RNA-based therapeutic consisting of microRNA 6883-5p (miR-6883) encapsulated within a lipid nanoparticle (LNP) delivery system. Developed by SMURF Therapeutics in collaboration with Brown University, the drug functions by silencing the expression of cyclin-dependent kinases 4 and 6 (CDK4/6). This inhibition triggers the degradation of Hypoxia-Inducible Factor 1α (HIF1α) via the E3 ubiquitin ligase SMURF2, effectively targeting both cell cycle progression and hypoxia-driven survival pathways in cancer cells. Preclinical data presented at AACR 2026 demonstrated significant anti-tumor activity in colorectal and breast cancer models, particularly when combined with MEK inhibitors or ferroptosis-inducing agents.
- Other names
- miR-6883miR6883miR 6883microRNA 6883-5p lipid nanoparticlesmicroRNA6883-5p lipid nanoparticlesmicroRNA-6883-5p lipid nanoparticlesmiR-6883-5pmiR6883-5pmiR 6883-5p
02
Targets
CDK6 (Cyclin-dependent kinase 6)CDK4 (Cyclin-dependent kinase 4)HIF1A (Hypoxia-inducible factor 1-alpha)
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