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miRNA-loaded EVs
- Development stage
- Preclinical
- Lead developer
- Theramir
- Modality
- RNA Therapeutics → Nucleic Acid Therapeutics, Lipid-based Nanoparticles → Nanoparticles → Drug Delivery Systems
- Administration
- Intravenous
01
Overview
miRNA-loaded EVs is a preclinical therapeutic candidate developed by Theramir using its proprietary EVmiR platform. This approach utilizes extracellular vesicles (EVs) as delivery vehicles for specific microRNA (miRNA) sequences designed to target and modulate oncoproteins that are dysregulated in cancer, particularly breast cancer. By delivering these miRNAs directly to tumor cells, the therapy aims to disrupt metastatic processes and inhibit tumor growth. The platform leverages the natural ability of EVs to transport molecular cargo between cells, providing a biocompatible and potentially more effective method for RNA interference therapy compared to traditional delivery systems. The asset is currently in the preclinical stage of development, focusing on the selective targeting of tumors and the modulation of key oncogenic pathways.
- Other names
- Theramir-oncoproteins dysregulated in cancer-microRNA-extracellular vesicles (EVs)-breast cancerEVmiRmiRNA-loaded extracellular vesiclesEXCELL project
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