miroliver

Miroliver is a bioengineered, fully transplantable liver organ being developed by Miromatrix Medical Inc. (a subsidiary of United Therapeutics Corporation) for the treatment of end-stage liver disease (ESLD). The product is created using a proprietary perfusion decellularization and recellularization technology. This process involves removing porcine cells from a harvested pig liver to create a decellularized extracellular matrix scaffold that retains the original organ's mechanical and vascular architecture. This scaffold is then recellularized with functional human cells, including hepatocytes and endothelial cells, to produce a functional, transplantable organ. The technology aims to address the critical shortage of donor organs for liver transplantation by providing a bioengineered alternative that can be surgically implanted to restore hepatic function.

Other names

miroliver (transplantable)bioengineered liver