Clinical trials
Follow clinical development from study design and recruitment through results.
- Trial phase
- Status
- Readouts
Drug intelligence / Profile preview
mirtazapine
- Development stage
- Approved
- Lead developer
- Organon
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
Mirtazapine is an atypical tetracyclic antidepressant primarily used to treat major depressive disorder in adults. It is also prescribed off-label for conditions such as anxiety disorders, insomnia, obsessive compulsive disorder (OCD), post-traumatic stress disorder (PTSD), and to stimulate appetite. The drug acts mainly by antagonizing central presynaptic alpha 2 adrenergic inhibitory autoreceptors and heteroreceptors, which increases the release of norepinephrine and serotonin. Additionally, it is a potent antagonist or inverse agonist at histamine H1 receptors and serotonin 5‑HT2A/5‑HT2C/5‑HT3 receptors. Unlike many other antidepressants, mirtazapine does not inhibit the reuptake of monoamines nor does it inhibit monoamine oxidase[1][4][5][7]. It was originally developed by Organon.
- Brand names
- RemeronRemeron SolTabAvanzaAxitMirtabeneMirtazMirtazonNorsetPromyrtilRemergilRemergonRexerZispin
- Other names
- mirtazapinamirtazapin
02
Targets
ADRA2A (α2A)HRH1 (Histamine H1 Receptor)HTR2A (Serotonin receptor 5-HT2A)HTR2C (5-hydroxytryptamine 2C receptor)HTR3A (5-hydroxytryptamine receptor 3A)
Beyond the preview
Go deeper on mirtazapine.
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Indications & development
Explore development by indication, patient population, and geography.
- Indications
- Development status
- Countries
Licensing & deals
Trace asset ownership, licensing agreements, and commercial partnerships.
- Partners
- Deal terms
- Milestones
Patents & exclusivity
Explore the patent landscape and regulatory exclusivity around an asset.
- Patents
- Expiration dates
- Exclusivity
Competitive landscape
Compare development programs by target, modality, and indication.
- Competing assets
- Targets
- Development stage
Research & analysis
Connect source evidence and development news to your research questions.
- Publications
- News
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on mirtazapine.