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misoprostol + oxytocin
- Development stage
- Phase 4
- Modality
- Small Molecules
- Administration
- Oral, Sublingual, Vaginal, Rectal, Intrauterine, Intramuscular
01
Overview
A combination of two uterotonic drugs used primarily for the prevention and treatment of postpartum hemorrhage (PPH). Misoprostol is a synthetic prostaglandin E1 analog that stimulates uterine contractions, while oxytocin is a hormone that induces rapid uterine contractions. When used together, they provide synergistic effects - oxytocin's immediate action combined with misoprostol's sustained effect on uterine contractility creates a more effective treatment for preventing and managing postpartum hemorrhage than either drug alone.
- Other names
- oxytocin plus intrauterine misoprostolintrauterine misoprostol and oxytocin
02
Targets
AVPR1A (Arginine vasopressin receptor 1A)AVPR1B (Vasopressin V1b Receptor)MOR (Mu opioid receptor)Oxytocin receptorPTGER2 (Prostaglandin E2 receptor EP2)PTGER3 (Prostaglandin E2 receptor EP3 subtype)PTGER4 (Prostaglandin E2 receptor EP4 subtype)TRPV1 (Transient receptor potential cation channel subfamily V member 1)PTGER (Prostaglandin E2 receptor)
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