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misoprostol + oxytocin
- Development stage
- Unknown
- Modality
- Small Molecules
- Administration
- Oral, Sublingual, Vaginal, Rectal, Intrauterine, Intramuscular
01
Overview
A combination of two uterotonic drugs used primarily for the prevention and treatment of postpartum hemorrhage (PPH). Misoprostol is a synthetic prostaglandin E1 analog that stimulates uterine contractions, while oxytocin is a hormone that induces rapid uterine contractions. When used together, they provide synergistic effects - oxytocin's immediate action combined with misoprostol's sustained effect on uterine contractility creates a more effective treatment for preventing and managing postpartum hemorrhage than either drug alone.
- Brand names
- Cytotec
- Other names
- oxytocin plus intrauterine misoprostolintrauterine misoprostol and oxytocin
02
Targets
AVPR1A (Arginine vasopressin receptor 1A)TRPV1 (Transient receptor potential cation channel subfamily V member 1)AVPR1B (Vasopressin V1b Receptor)Oxytocin receptorPTGER3 (Prostaglandin E2 receptor EP3 subtype)PTGER4 (Prostaglandin E2 receptor EP4 subtype)MOR (Mu opioid receptor)PTGER2 (Prostaglandin E2 receptor EP2)
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